EXPLORING THE INSULIN SECRETORY PROPERTIES OF THE PGD2-GPR44/DP2 AXIS IN VITRO AND IN A RANDOMIZED PHASE-1 TRIAL OF TYPE 2 DIABETES PATIENTS.

Exploring the insulin secretory properties of the PGD2-GPR44/DP2 axis in vitro and in a randomized phase-1 trial of type 2 diabetes patients.

AIMS/HYPOTHESIS:GPR44 (DP2, PTGDR2, CRTh2) is the receptor for the pro-inflammatory mediator prostaglandin D2 (PGD2) and it is enriched in human islets.In rodent islets, PGD2 is produced in response to glucose, suggesting that the PGD2-GPR44/DP2 axis may play a role in human islet function during hyperglycemia.Consequently, the aim of this work was

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Identifying the morphologic basis for radiomic features in distinguishing different Gleason grades of prostate cancer on MRI: Preliminary findings.

Translation of radiomics into the clinic may require a more comprehensive understanding of the underlying morphologic tissue characteristics they reflect.In the context of prostate cancer (PCa), some studies have correlated gross histological measurements of gland lumen, epithelium, and nuclei with disease appearance on MRI.Quantitative histomorpho

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Approaching Modern Monetary Theory with a Taylor Rule

Considering the goals of Modern Monetary Theorists, this article examines inflation stabilization and employment maximization through a Taylor Rule for fiscal policy, similar to John Taylor’s foundational examination of the behavior of the Federal NEFF N30 U1CHC0AN0B Electric Double Oven - Stainless Steel Reserve.If it is the role of the fede

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Insights from the management of offshore energy resources: Toward an ecosystem-services based management approach for deep-ocean industries

The deep ocean comprises complex ecosystems made up of numerous community Halloween and habitat types that provide multiple services that benefit humans.As the industrialization of the deep sea proceeds, a standardized and robust set of methods and metrics need to be developed to monitor the baseline conditions and any anthropogenic and climate cha

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